Premature Adrenarche - A Common Condition with Variable Presentation

Premature adrenarche--a common condition with variable presentation.

Adrenarche refers to a maturational increase in the secretion of adrenal androgen precursors, mainly dehydroepiandrosterone (DHEA) and its sulfate (DHEAS). In premature adrenarche (PA), clinical signs of androgen action appear before the age of 8/9 years in girls/boys, concurrently with the circulating DHEA(S) concentrations above the usually low prepubertal level. The most pronounced sign of P...

Normal and Premature Adrenarche

Genetic Variation in Premature Adrenarche

Premature adrenarche (PA) is defined as adrenarcheal levels of adrenal androgens before the age of 8 yrs in girls and the age of 9 yrs in boys leading to androgenic signs ranging from pubarche to oily skin and adult type body odor. PA has been connected with adverse metabolic features and increased risk for ovarian hyperandrogenism. The pathogenesis of PA is considered polygenic. However, under...

Verrucous Lichen Planus: A Rare Presentation of a Common Condition

Lichen planus is a chronic papulosquamous dermatoses in which both skin and mucosae are involved. There are various morphological forms of lichen planus. Hypertrophic lichen planus is one of the rare clinical variants. Herein, we report a very unusual presentation of hypertrophic lichen planus. A similar presentation has not been reported in literature yet, to the best of our knowledge.

Hidradenitis suppurativa as a presenting feature of premature adrenarche.

We report a girl with premature adrenarche, in whom the presenting feature was hidradenitis suppurativa. This association lends support to the view that hidradenitis suppurativa is an androgen-dependent disorder.